Dhx57^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dhx57^em1(IMPC)J
• Name: DExH-box helicase 57; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7446978
• Gene: Dhx57 Location: Chr17:80545733-80597620 bp, - strand Genetic Position: Chr17, 50.63 cM
• Alliance: Dhx57^em1(IMPC)J page
• IMPC: Dhx57 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ACAGTATTGCTCCTAGGGAC and AGATGAAACCAGCAACTGAA, which resulted in a 1411 bp deletion beginning at Chromosome 17 position 80,274,741 bp and ending after 80,276,151 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000251581 and ENSMUSE00000251553 (exons 4 and 5) and 386 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 129 and early truncation 11 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dhx57 Mutation: 89 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)