Nxpe4^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nxpe4^em1(IMPC)J
• Name: neurexophilin and PC-esterase domain family, member 4; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7447104
• Gene: Nxpe4 Location: Chr9:48073321-48311325 bp, + strand Genetic Position: Chr9, 26.39 cM
• Alliance: Nxpe4^em1(IMPC)J page
• IMPC: Nxpe4 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TTCTTGGTCCATAGTAGGCA and GTGACCAAGTCCAACAGAAA, which resulted in a 464 bp deletion beginning at Chromosome 9 position 48,393,961 bp and ending after 48,394,424 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000334056 (exon 7) and 402 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 275 and early truncation 19 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nxpe4 Mutation: 35 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)