Gt(ROSA)26Sor^{tm9(CAG-CHRM4*,-ZsGreen)Jcbr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm9(CAG-CHRM4*,-ZsGreen)Jcbr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jens C Bruning
• MGI ID: MGI:7463980
• Synonyms: Gt(ROSA)26Sor^{tm1(CAG-CHRM4*,-ZsGreen)Fens}, R26-LSL-RSR-hM4Di-ZsGreen
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm9(CAG-CHRM4*,-ZsGreen)Jcbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314805
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP-flanked STOP cassette and a rox-flanked STOP cassette preventing the CAG promoter-driven expression of the modified human muscarinic 4 receptor (CHRM4) sequence hM4Di and ZsGreen separated by 2A. (J:314805)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 958 strains or lines available

References

• Original: J:314805 Borgmann D, et al., Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 Jul 6;33(7):1466-1482.e7
• All: 1 reference(s)