Gpr65^em1Xav
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr65^em1Xav
• Name: G-protein coupled receptor 65; endonuclease-mediated mutation 1, Ramnik J Xavier
• MGI ID: MGI:7466795
• Synonyms: I231L
• Gene: Gpr65 Location: Chr12:98234894-98242903 bp, + strand Genetic Position: Chr12, 49.84 cM
• Alliance: Gpr65^em1Xav page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated an A to C change resulting in an isoleucine to leucine substitution at amino acid 231 (p.I231L). (J:335105)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr65 Mutation: 21 strains or lines available

References

• Original: J:335105 Chen X, et al., pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells. Nat Immunol. 2022 Jul;23(7):1063-1075
• All: 2 reference(s)