Ace2^em1Mccc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1Mccc
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Maria Cecilia C Canesso
• MGI ID: MGI:7468713
• Synonyms: Ace2^H353K
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1Mccc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a histidine to lysine substitution at amino acid 353 (p.H353K) in exon 9. K353 is a residue at the core of the ACE2-RBD interaction in humans which has been shown to allow replication of the original SARS coronavirus in mouse cells. (J:335150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:335150 Nakandakari-Higa S, et al., A minimally-edited mouse model for infection with multiple SARS-CoV-2 strains. Front Immunol. 2022;13:1007080
• All: 1 reference(s)