Tg(APOL1*)G2Mrpk
Transgene Detail

Summary

• Symbol: Tg(APOL1*)G2Mrpk
• Name: transgene insertion G2, Martin R Pollak
• MGI ID: MGI:7469469
• Synonyms: APOL1^G2
• Transgene: Tg(APOL1*)G2Mrpk Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Tg(APOL1*)G2Mrpk page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR-targeting of Tg(APOL1*)G1Mrpk deleting amino acids 388-389 resulting in the G2 haplotype. (J:322919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:322919 McCarthy GM, et al., Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 Aug 1;14(8):dmm048952
• All: 2 reference(s)