Mov10^tm1.1Jw
Targeted Allele Detail

Summary

• Symbol: Mov10^tm1.1Jw
• Name: Mov10 RISC complex RNA helicase; targeted mutation 1.1, Jeremy Wang
• MGI ID: MGI:7484085
• Synonyms: Mov10^fl
• Gene: Mov10 Location: Chr3:104702152-104725879 bp, - strand Genetic Position: Chr3, 45.87 cM, cytoband F2
• Alliance: Mov10^tm1.1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335634
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 8 through 14. Cre-mediated recombination removed the selection cassette. (J:335634)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mov10 Mutation: 76 strains or lines available

References

• Original: J:335634 Guan Y, et al., The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice. PLoS Genet. 2023 May;19(5):e1010566
• All: 1 reference(s)