Sftpctm1.1Twv
Targeted Allele Detail
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Symbol: |
Sftpctm1.1Twv |
Name: |
surfactant associated protein C; targeted mutation 1.1, Timothy E Weaver |
MGI ID: |
MGI:7506448 |
Synonyms: |
L184Q, LQ |
Gene: |
Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
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Alliance: |
Sftpctm1.1Twv page
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Germline Transmission: |
Earliest citation of germline transmission:
J:313007
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: The following elements were inserted immediately downstream of exon 1: coding cDNA sequence for exons 2-5 where exon 5 has a T-to-A point mutation changing leucine codon 184 to glutamine (p.L184Q), triple stop codons, bovine growth hormone gene poly(A) signal sequences and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation mimics the p.L188Q human mutation associated with lung disease.
(J:313007)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sftpc Mutation: |
23 strains or lines available
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Original: |
J:313007 Sitaraman S, et al., Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI Insight. 2021 Jul 22;6(14) |
All: |
1 reference(s) |
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