Psmc5tm1.1Genp
Targeted Allele Detail
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Symbol: |
Psmc5tm1.1Genp |
Name: |
protease (prosome, macropain) 26S subunit, ATPase 5; targeted mutation 1.1, Gentry N Patrick |
MGI ID: |
MGI:7506899 |
Synonyms: |
Rpt6 S120D |
Gene: |
Psmc5 Location: Chr11:106147011-106153938 bp, + strand Genetic Position: Chr11, 68.89 cM, cytoband E1
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Alliance: |
Psmc5tm1.1Genp page
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Germline Transmission: |
Earliest citation of germline transmission:
J:308469
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Parent Cell Line: |
BAC-BA1 (ES Cell)
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Strain of Origin: |
(C57BL/6 x 129S/SvEv)F1
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Allele Type: |
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Targeted (Not Specified) |
Mutation: |
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Nucleotide substitutions
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Mutation details: Serine codon 120 (AGC) in exon 5 was changed to aspartic acid (GAC) (p.S120D) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation turns the affected residue in the encoded peptide from phosphorylatable to a phosphomimetic.
(J:308469)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Psmc5 Mutation: |
31 strains or lines available
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Original: |
J:308469 Scudder SL, et al., Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning. eNeuro. 2021 May-Jun;8(3):ENEURO.0073-20.2021 |
All: |
1 reference(s) |
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