Cfiem2Jiwe
Endonuclease-mediated Allele Detail
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Symbol: |
Cfiem2Jiwe |
Name: |
complement component factor i; endonuclease-mediated mutation 2, Jiqiu Wen |
MGI ID: |
MGI:7507066 |
Synonyms: |
CFI-P467S |
Gene: |
Cfi Location: Chr3:129630432-129668978 bp, + strand Genetic Position: Chr3, 59.21 cM
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Alliance: |
Cfiem2Jiwe page
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Strain of Origin: |
Not Applicable
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Allele Type: |
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Endonuclease-mediated (Humanized sequence) |
Mutation: |
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Single point mutation
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Mutation details: Proline codon 467 (CCC) in exon 12 was changed to serine (TCC) (p.P467S) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.P447S mutation associated with C3 glomerulonephritis (C3GN).
(J:308307)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cfi Mutation: |
44 strains or lines available
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Original: |
J:308307 Song H, et al., Generation and Characterization of Mouse Models of C3 Glomerulonephritis With CFI D288G and P467S Mutations. Front Physiol. 2021;12:649801 |
All: |
1 reference(s) |
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