Tg(ACTA1-Lrp4)#Line
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Lrp4)#Line
• Name: transgene insertion, Lin Mei
• MGI ID: MGI:7507170
• Synonyms: HSA::LRP4-FL^Tg, LRP4-FLtg
• Transgene: Tg(ACTA1-Lrp4)#Line Location: unknown
• Alliance: Tg(ACTA1-Lrp4)#Line page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-Lrp4)#Line expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lrp4 (MGI:2442252)	human promoter, N-terminal FLAG tag, mouse cDNA

• Tg(ACTA1-Lrp4)#Line expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: The transgene contains the following elements: human skeletal muscle actin alpha 1 promoter, polyomavirus capsid protein gene VP1, signal peptide sequence, FLAG tag sequence in-frame with mouse low density lipoprotein receptor-related protein 4 cDNA sequence, IRES sequence, GFP reporter gene, and SV40 poly(A) signal sequences. (J:266450)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:266450 Zhao K, et al., Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. J Neurosci. 2018 Oct 10;38(41):8860-8873
• All: 4 reference(s)