Pdcd1lg2^em1Okat
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pdcd1lg2^em1Okat
• Name: programmed cell death 1 ligand 2; endonuclease-mediated mutation 1, Taku Okazaki
• MGI ID: MGI:7511848
• Gene: Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
• Alliance: Pdcd1lg2^em1Okat page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination using a guide RNA (5'-cggtcaaaatcgcactcc-3') created a 1 bp insertion (a) resulting in a frameshift and premature stop codon. (J:338344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1lg2 Mutation: 23 strains or lines available

References

• Original: J:338344 Sugiura D, et al., PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nat Immunol. 2022 Mar;23(3):399-410
• All: 1 reference(s)