Cbx7tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Cbx7tm1c(KOMP)Wtsi |
Name: |
chromobox 7; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7512758 |
Synonyms: |
Cbx7fl, Cbx7floxed |
Gene: |
Cbx7 Location: Chr15:79800008-79855320 bp, - strand Genetic Position: Chr15, 37.85 cM
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Alliance: |
Cbx7tm1c(KOMP)Wtsi page
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IMPC: |
Cbx7 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:338403
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Parent Cell Line: |
JM8 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_gt2 cassette was inserted at position 79806078 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 79806185. The critical exon(s) is/are thus flanked by loxP sites.A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:338403)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cbx7 Mutation: |
234 strains or lines available
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Original: |
J:338403 Cho KW, et al., Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. Circulation. 2023 Jun 13;147(24):1823-1842 |
All: |
1 reference(s) |
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