Kpna2^em2Alfon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kpna2^em2Alfon
• Name: karyopherin subunit alpha 2; endonuclease-mediated mutation 2, Alfonso Gutierez-Adan
• MGI ID: MGI:7512793
• Synonyms: Kpna2^-7
• Gene: Kpna2 Location: Chr11:106879455-106890351 bp, - strand Genetic Position: Chr11, 70.08 cM
• Alliance: Kpna2^em2Alfon page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an 8-bp (AACCTGTT) deletion in exon 2 predicted to result in a frameshift and early chain termination due to a premature stop codon and generate a 31 amino acid protein instead of the 529 amino acid wild-type protein. This allele represents line 7. (J:338393)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpna2 Mutation: 43 strains or lines available

References

• Original: J:338393 Navarrete-Lopez P, et al., Loss of the importin Kpna2 causes infertility in male mice by disrupting the translocation of testis-specific transcription factors. iScience. 2023 Jul 21;26(7):107134
• All: 1 reference(s)