Ace2^em1(ACE2)Rlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1(ACE2)Rlu
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Rudolf Lucas
• MGI ID: MGI:7524682
• Synonyms: hACE2 KI
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1(ACE2)Rlu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• CRISRP/Cas9 technology replaced exon 2 with human ACE2. (J:339692)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:339692 Romero MJ, et al., Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein. Front Immunol. 2023;14:1241448
• All: 1 reference(s)