Wt1^{tm2.1(cre/ERT2)Wtp}
Targeted Allele Detail

Summary

• Symbol: Wt1^{tm2.1(cre/ERT2)Wtp}
• Name: WT1 transcription factor; targeted mutation 2.1, William T Pu
• MGI ID: MGI:7528785
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^{tm2.1(cre/ERT2)Wtp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237690
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Wt1^{tm2.1(cre/ERT2)Wtp} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Wt1 (MGI:98968)

• Mutation details: Exon 1 was replaced with an inducible cre ESR1 (ERT2) fusion followed by an FRT-flanked neo cassette. Flp-mediated recombination removed the selection cassette. (J:137426, J:237690)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Wt1 (mouse) Summary of all recombinase alleles driven by Wt1. Alliance mouse Wt1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:237690 Da Costa CR, Deletion of FRT-flanked neo cassette from Grem1^tm1Ecan. Personal Communication. 2016
• All: 2 reference(s)