Scgb3a2^{em1(dre/ERT2)Brst}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scgb3a2^{em1(dre/ERT2)Brst}
• Name: secretoglobin, family 3A, member 2; endonuclease-mediated mutation 1, Barry R Stripp
• MGI ID: MGI:7531065
• Synonyms: Scgb3a2-DreER
• Gene: Scgb3a2 Location: Chr18:43897354-43900464 bp, + strand Genetic Position: Chr18, 23.49 cM, cytoband C-D
• Alliance: Scgb3a2^{em1(dre/ERT2)Brst} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Scgb3a2^{em1(dre/ERT2)Brst} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scgb3a2 (MGI:2153470)

• Mutation details: Using a CRISPR/Cas9 knock-in strategy, an IRES-DreERT2 construct was inserted into the 3 UTR of the mouse Scgb3a2 gene. (J:340765)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scgb3a2 (mouse) Summary of all recombinase alleles driven by Scgb3a2. Alliance mouse Scgb3a2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scgb3a2 Mutation: 12 strains or lines available

References

• Original: J:340765 Beppu AK, et al., Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection. Nat Commun. 2023 Sep 19;14(1):5814
• All: 1 reference(s)