Bcl2l11^tm1.2Rsky
Targeted Allele Detail

Summary

• Symbol: Bcl2l11^tm1.2Rsky
• Name: BCL2 like 11; targeted mutation 1.2, Klaus Rajewsky
• MGI ID: MGI:7541072
• Gene: Bcl2l11 Location: Chr2:127967958-128004467 bp, + strand Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
• Alliance: Bcl2l11^tm1.2Rsky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284194
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 4 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 4 followed by a mutated exon 4 lacking the 3'UTR. FLP-mediated recombination removed the selection cassette and left the wild-type exon 4 floxed. Cre-mediated recombination removed exon 4. (J:284194)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l11 Mutation: 33 strains or lines available

References

• Original: J:284194 Labi V, et al., Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat. Genes Dev. 2019 Dec 1;33(23-24):1673-1687
• All: 1 reference(s)