Sirt1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sirt1^em1Cya
• Name: sirtuin 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7543446
• Synonyms: Sirt1^flox
• Gene: Sirt1 Location: Chr10:63154784-63174814 bp, - strand Genetic Position: Chr10, 32.57 cM
• Alliance: Sirt1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 technology generated a conditional (floxed) allele. (J:341705)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt1 Mutation: 78 strains or lines available

References

• Original: J:341705 Jiang T, et al., SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc. Redox Biol. 2023 Jan 24;60:102615
• All: 1 reference(s)