Agr2^tm1.1Erle
Targeted Allele Detail

Summary

• Symbol: Agr2^tm1.1Erle
• Name: anterior gradient 2; targeted mutation 1.1, David J Erle
• MGI ID: MGI:7543972
• Synonyms: Agr2loxP
• Gene: Agr2 Location: Chr12:36042924-36054080 bp, + strand Genetic Position: Chr12, 16.18 cM
• Alliance: Agr2^tm1.1Erle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148339
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed by insertion of a loxP site upstream of exon 2 and the addition of a FRT-neo-loxP-FRT-loxP cassette downstream of exon 3. The neo cassette was subsequently removed from correctly targeted ES cells by transient expression of FLPe recombinase. (J:148339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agr2 Mutation: 31 strains or lines available

References

• Original: J:148339 Park SW, et al., The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6950-5
• All: 1 reference(s)