Gt(ROSA)26Sor^{tm3(CAG-KIT*)Geno}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(CAG-KIT*)Geno}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Genoway
• MGI ID: MGI:7546869
• Synonyms: Gt(ROSA)26Sor^tm1(KIT)Geno, Rosa^LSL-Kitc
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(CAG-KIT*)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: GenOways quick knock-in approach was used to insert into the locus a CAG promoter, floxed neomycin resistance and STOP cassette, and the human mutated KIT with an exon 11 codons 557-558 deletion mutation. (J:300991)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 997 strains or lines available

References

• Original: J:300991 Kondo J, et al., A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin. J Pathol. 2020 Dec;252(4):441-450
• All: 1 reference(s)