Pura^em1Tht
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pura^em1Tht
• Name: purine rich element binding protein A; endonuclease-mediated mutation 1, Tse-Hua Tan
• MGI ID: MGI:7546878
• Synonyms: Pur-alpha KO
• Gene: Pura Location: Chr18:36414150-36425588 bp, + strand Genetic Position: Chr18, 19.46 cM, cytoband B3
• Alliance: Pura^em1Tht page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a thirty-four nucleotide deletion encompassing the start codon (ATG). (J:342156)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pura Mutation: 26 strains or lines available

References

• Original: J:342156 Chuang HC, et al., DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. J Clin Invest. 2023 Nov 1;133(21)
• All: 1 reference(s)