Slc2a12^em2Stky
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc2a12^em2Stky
• Name: solute carrier family 2 (facilitated glucose transporter), member 12; endonuclease-mediated mutation 2, Hiroshi Suzuki
• MGI ID: MGI:7547161
• Synonyms: Glut12^128del, Glut12/Uox DKO #2
• Gene: Slc2a12 Location: Chr10:22520910-22580184 bp, + strand Genetic Position: Chr10, 10.21 cM
• Alliance: Slc2a12^em2Stky page

Mutation origin

• Strain of Origin: C57BL/6J x B6;129S7-Uox^tm1Bay/J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 128 bp deletion in exon 2 resulting in a frame-shift mutation. This allele was generated in zygotes from wild-type eggs and Uox^tm1Bay sperm and thus is null for both Slc2a12 and Uox. (J:295905)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a12 Mutation: 41 strains or lines available

References

• Original: J:295905 Toyoda Y, et al., Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18175-18177
• All: 2 reference(s)