Col1a1^{tm1(tetO-Cpt1a,-GFP)Slms}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-Cpt1a,-GFP)Slms}
• Name: collagen, type I, alpha 1; targeted mutation 1, Santiago Lamas
• MGI ID: MGI:7564295
• Synonyms: CPT1A^tetO, tetO-Cpt1a^tg
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-Cpt1a,-GFP)Slms} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305068
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: RMCE inserted the tetracycline response element driving inducible expression of the mouse gene and reporter gene. (J:305068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 161 strains or lines available

References

• Original: J:305068 Miguel V, et al., Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis. J Clin Invest. 2021 Mar 1;131(5)
• All: 2 reference(s)