Fbxl12tm1.1Lov
Targeted Allele Detail
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Symbol: |
Fbxl12tm1.1Lov |
Name: |
F-box and leucine-rich repeat protein 12; targeted mutation 1.1, Paul E Love |
MGI ID: |
MGI:7565496 |
Synonyms: |
Fbxl12fl |
Gene: |
Fbxl12 Location: Chr9:20549045-20556064 bp, - strand Genetic Position: Chr9, 7.59 cM, cytoband A3
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Alliance: |
Fbxl12tm1.1Lov page
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Germline Transmission: |
Earliest citation of germline transmission:
J:280728
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The targeting vector obtained from KOMP is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4. The critical exon 4 is thus flanked by loxP sites. The neomycin resistance gene was removed via flp-mediated recombination resulting in a conditional ready (floxed) allele.
(J:280728)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fbxl12 Mutation: |
28 strains or lines available
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Original: |
J:280728 Zhao B, et al., Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12. Nat Immunol. 2019 Oct;20(10):1381-1392 |
All: |
1 reference(s) |
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