Tut7^em1Lchs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tut7^em1Lchs
• Name: terminal uridylyl transferase 7; endonuclease-mediated mutation 1, Li-Chung Hsu
• MGI ID: MGI:7571531
• Gene: Tut7 Location: Chr13:59919690-59971060 bp, - strand Genetic Position: Chr13, 31.88 cM
• Alliance: Tut7^em1Lchs page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to generate a deletion of exons 2-26. (J:343914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tut7 Mutation: 68 strains or lines available

References

• Original: J:343914 Lin CC, et al., Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation. Nat Commun. 2021 Jun 29;12(1):3878
• All: 1 reference(s)