Wwtr1^tm1.2Hmc
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1.2Hmc
• Name: WW domain containing transcription regulator 1; targeted mutation 1.2, Helen McNeill
• MGI ID: MGI:7581994
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1.2Hmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and a loxP site and FRT-flanked neo cassette were inserted in intron 2 via homologous recombination. Breeding to Flpe-expressing mice removed the FRT-flanked NEO. (J:195266)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

Notes

The version of this allele that contains the neo cassette, Wwtr1^tm1Hmc, has been analyzed.

References

• Original: J:195266 Reginensi A, et al., Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
• All: 12 reference(s)