Cdkl5^tm1.1Arikk
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm1.1Arikk
• Name: cyclin dependent kinase like 5; targeted mutation 1.1, Jyothi Arikkath
• MGI ID: MGI:7587841
• Synonyms: CDKL5 Flox
• Gene: Cdkl5 Location: ChrX:159567241-159777673 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm1.1Arikk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281989
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A LoxP site was inserted in intron 3 and a Frt-Neo-Frt-LoxP cassette was inserted in intron 4. Flp-mediated recombination in the germline resulted in the removal of the promoter-driven neomycin selection cassette. (J:281989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 20 strains or lines available

References

• Original: J:281989 Schroeder E, et al., Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers. Mol Neurobiol. 2019 Jun;56(6):4151-4162
• All: 1 reference(s)