Max^tm1.1Rne
Targeted Allele Detail

Summary

• Symbol: Max^tm1.1Rne
• Name: Max protein; targeted mutation 1.1, Robert N Eisenman
• MGI ID: MGI:7606240
• Synonyms: Max^fl
• Gene: Max Location: Chr12:76984043-77008975 bp, - strand Genetic Position: Chr12, 33.78 cM, cytoband D1-D3
• Alliance: Max^tm1.1Rne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284176
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT-flanked pGKNeobpA cassette was designed to insert loxP sites on either side of exon 4. Flp-mediated recombination removed the selection cassette. (J:284176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Max Mutation: 32 strains or lines available

References

• Original: J:284176 Mathsyaraja H, et al., Max deletion destabilizes MYC protein and abrogates Emicro-Myc lymphomagenesis. Genes Dev. 2019 Sep 1;33(17-18):1252-1264
• All: 3 reference(s)