Mir137^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Mir137^tm1.2Ics
• Name: microRNA 137; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:7616509
• Synonyms: Mir137^-, Mir137^tm2.1Ics
• Gene: Mir137 Location: Chr3:118227506-118227578 bp, + strand Genetic Position: Chr3, 51.71 cM
• Alliance: Mir137^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342743
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream and an FRT site flanked neomycin resistance gene cassette and second loxP site were inserted downstream. The neo cassette was removed through subsequent Flp-mediated recombination, leaving the locus floxed. The locus was deleted through subsequent Cre-mediated recombination. Mutations in the human ortholog are associated with intellectual disability, autism and schizophrenia. (J:342743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir137 Mutation: 5 strains or lines available

References

• Original: J:342743 Meziane H, et al., Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models. Biomedicines. 2022 Dec 6;10(12)
• All: 1 reference(s)