Phf6tm1.1Ics
Targeted Allele Detail
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Symbol: |
Phf6tm1.1Ics |
Name: |
PHD finger protein 6; targeted mutation 1.1, Mouse Clinical Institute |
MGI ID: |
MGI:7616514 |
Gene: |
Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
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Alliance: |
Phf6tm1.1Ics page
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Germline Transmission: |
Earliest citation of germline transmission:
J:342743
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and second loxP site were inserted into intron 5. The neo cassette was removed through subsequent Flp-mediated recombination, leaving exons 4-5 floxed. Mutations in the human ortholog are associated with Borjeson-Forssman-Lehmann syndrome (BFLS).
(J:342743)
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Original: |
J:342743 Meziane H, et al., Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models. Biomedicines. 2022 Dec 6;10(12) |
All: |
1 reference(s) |
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