Thsd4tm1.1Lysa
Targeted Allele Detail
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Symbol: |
Thsd4tm1.1Lysa |
Name: |
thrombospondin, type I, domain containing 4; targeted mutation 1.1, Lynn Y Sakai |
MGI ID: |
MGI:7618764 |
Gene: |
Thsd4 Location: Chr9:59874214-60429329 bp, - strand Genetic Position: Chr9, 32.38 cM
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Alliance: |
Thsd4tm1.1Lysa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:346290
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: Exon 2 of the beta form, which is exon 8 of the alpha form, was flanked by loxP sites and an FRT-flanked neomycin cassette was inserted. This codes for part of the spacer region, a motif shared by other members of this family. Flp-mediated recombination removed the neomycin cassette leaving exon 2/8 floxed.
(J:346290)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Thsd4 Mutation: |
37 strains or lines available
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Original: |
J:346290 Elbitar S, et al., Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm. Genet Med. 2021 Jan;23(1):111-122 |
All: |
1 reference(s) |
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