Eedtm1.2Mbu
Targeted Allele Detail
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Symbol: |
Eedtm1.2Mbu |
Name: |
embryonic ectoderm development; targeted mutation 1.2, Meinrad Busslinger |
MGI ID: |
MGI:7620301 |
Synonyms: |
Eeddelta |
Gene: |
Eed Location: Chr7:89603862-89630184 bp, - strand Genetic Position: Chr7, 50.42 cM
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Alliance: |
Eedtm1.2Mbu page
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Allele Type: |
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Targeted (Reporter) |
Mutation: |
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Insertion
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Mutation details: The targeting construct inserted a loxP upstream of the cDNA encoding exon 6 through 10 followed by the 3'UTR, six polyadenylation sequences, and loxP site upstream of exon 6. Additionally, a GFP reporter gene was inserted at the end of exon 6 followed by a polyadenylation sequence. Flp-mediated recombination removed the self-excising, FRT-flanked selection cassette. Cre-mediated recombination removed the cDNA encoding exons 6 through 10, allowing expression of the GFP reporter gene.
(J:294166)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Eed Mutation: |
116 strains or lines available
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Original: |
J:294166 Hill L, et al., Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion. Nature. 2020 Aug;584(7819):142-147 |
All: |
1 reference(s) |
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