Notch3^em1Tch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Notch3^em1Tch
• Name: notch 3; endonuclease-mediated mutation 1, Talal A Chatila
• MGI ID: MGI:7624470
• Synonyms: Notch3^fl
• Gene: Notch3 Location: Chr17:32339794-32385826 bp, - strand Genetic Position: Chr17, 17.37 cM
• Alliance: Notch3^em1Tch page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert LoxP sequences in introns 4 and 9 to flank exons 5-9. (J:347529)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch3 Mutation: 94 strains or lines available

References

• Original: J:347529 Harb H, et al., Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity. 2021 Apr 22
• All: 1 reference(s)