Ighg2cem1Wliu
Endonuclease-mediated Allele Detail
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Symbol: |
Ighg2cem1Wliu |
Name: |
immunoglobulin heavy constant gamma 2C; endonuclease-mediated mutation 1, Wanli Liu |
MGI ID: |
MGI:7627370 |
Synonyms: |
mIgG2c-G400R |
Gene: |
Ighg2c Location: Chr12:113251009-113252552 bp, - strand Genetic Position: Chr12, 62.1 cM
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Alliance: |
Ighg2cem1Wliu page
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Allele Type: |
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Endonuclease-mediated (Humanized sequence) |
Mutation: |
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Single point mutation
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Mutation details: CRISPR/Cas9 technology generated a GGG to AGG change resulting in a glycine to arginine substitution at position 400 (p.G400R). The mouse G400R mutation corresponds to the human G396R protective Asia-specific variant for progression and survival of colorectal cancer patients.
(J:322180)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ighg2c Mutation: |
16 strains or lines available
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Original: |
J:322180 Yang B, et al., An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022 Mar 15;132(6):e153454 |
All: |
1 reference(s) |
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