Lrp1^tm2.1Her
Targeted Allele Detail

Summary

• Symbol: Lrp1^tm2.1Her
• Name: low density lipoprotein receptor-related protein 1; targeted mutation 2, Joachim Herz
• MGI ID: MGI:7657694
• Gene: Lrp1 Location: Chr10:127374030-127457017 bp, - strand Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
• Alliance: Lrp1^tm2.1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76281
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked PGK-neomycin selection cassette was inserted 240 bp upstream of the transcription initiation site, and a third loxP site was inserted 3' to exon 1 in intron 2. Cre-recombinase removed the PGK-neomycin selection cassette leaving the exon 1 flanked by loxP sites. (J:76281, J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp1 Mutation: 211 strains or lines available

References

• Original: J:76281 Rohlmann A, et al., Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nat Biotechnol. 1996 Nov;14(11):1562-5
• All: 3 reference(s)