Tnfsf11^em3Caob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfsf11^em3Caob
• Name: tumor necrosis factor (ligand) superfamily, member 11; endonuclease-mediated mutation 3, Charles A O'Brien
• MGI ID: MGI:7767874
• Synonyms: hRANKL
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^em3Caob page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination modified 4 amino acids in exon 5 (SVPTD to DLATE at positions 229-231 and 233) to replace the mouse epitope at this location with the human one. (J:357883)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 32 strains or lines available

References

• Original: J:357883 Fu Q, et al., Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation. JCI Insight. 2023 Sep 22;8(18)
• All: 1 reference(s)