Ets2^em1(IMPC)Ics
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ets2^em1(IMPC)Ics
• Name: E26 avian leukemia oncogene 2, 3' domain; endonuclease-mediated mutation 1, Mouse Clinical Institute
• MGI ID: MGI:7781818
• Gene: Ets2 Location: Chr16:95503274-95522093 bp, + strand Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
• Alliance: Ets2^em1(IMPC)Ics page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at the Institut Clinique de la Souris by electroporating Cas9 protein and 4 sgRNAs (equivalent to TTGACGGCGTGCTTTCTTAG, GGACCCATGGCAGGGTTACT,GGTCATTCTGGTGTCGTCAC and ACAGACAGTTCTCGGCTCAC), resulting in the deletion of exon 3 (ENSMUSE00001449193; GRCm39), leading to a frameshift and premature stop codon. (J:358405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ets2 Mutation: 39 strains or lines available

References

• Original: J:358405 MGI and ICS/MCI, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) Generated by ICS/MCI. Database Release. 2024
• All: 1 reference(s)