Dyrk1a^em1(IMPC)Ics
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dyrk1a^em1(IMPC)Ics
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; endonuclease-mediated mutation 1, Mouse Clinical Institute
• MGI ID: MGI:7781823
• Gene: Dyrk1a Location: Chr16:94370869-94496376 bp, + strand Genetic Position: Chr16, 55.3 cM
• Alliance: Dyrk1a^em1(IMPC)Ics page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: This allele was generated at the Institut Clinique de la Souris by co-electroporating Cas9 protein, a crRNA (CAAGCAGCCGCACTTCTATC)/tracrRNA and an ssODN template, which resulted in a p.A195T mutation in exon 6 (ENSMUSE00000131727; GRCm39). An XmnI diagnostic restriction site was introduced to facilitate genotyping. (J:358405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dyrk1a Mutation: 115 strains or lines available

References

• Original: J:358405 MGI and ICS/MCI, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) Generated by ICS/MCI. Database Release. 2024
• All: 1 reference(s)