Phenotypes Associated with This Genotype

Genotype
MGI:2166311

• Allelic
  Composition
• Genetic Background: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart left ventricle weight ( J:76471 )

• average left ventricular weight of 46.2mg is significantly higher than control A/J and results from an increase in the end-diastolic dimension and a proportional increase in wall thickness

decreased cardiac muscle contractility ( J:76471 )

• aortic ejection time is significantly longer than in A/J mice

decreased heart left ventricle muscle contractility ( J:268979 )

• average left ventricular shortening of 39.1 is significantly lower than the 47.1 in A/J mice

decreased heart rate ( J:76471 )

• average 433 beats per minute versus 524 in A/J

increased heart rate ( J:76471 )

• average heart rate is approximately 50 beats per minute higher than that in A/J

immune system

increased susceptibility to Coronaviridae infection ( J:268979 )

• moderately susceptible to mouse-adapted SARS-CoV infection, including moderate and transient weight loss

endocrine/exocrine glands

abnormal pineal gland morphology ( J:240797 )

• Background Sensitivity: the pineal gland is more flattened than that of CBA mice and there is a loss of volume associated with a loss of pinealocytes between 6 weeks and 10 months of age, when the pineal volume of CBA increases

abnormal pineal gland melatonin secretion ( J:240797 )

• Background Sensitivity: the C57BL/6J pineal gland is melatonin deficient

muscle

decreased cardiac muscle contractility ( J:76471 )

• aortic ejection time is significantly longer than in A/J mice

decreased heart left ventricle muscle contractility ( J:268979 )

• average left ventricular shortening of 39.1 is significantly lower than the 47.1 in A/J mice

nervous system

abnormal pineal gland morphology ( J:240797 )

• Background Sensitivity: the pineal gland is more flattened than that of CBA mice and there is a loss of volume associated with a loss of pinealocytes between 6 weeks and 10 months of age, when the pineal volume of CBA increases

abnormal pineal gland melatonin secretion ( J:240797 )

• Background Sensitivity: the C57BL/6J pineal gland is melatonin deficient

homeostasis/metabolism

enhanced exercise endurance ( J:76471 )

• exercise time on a treadmill is significantly greater than that of A/J