Phenotypes Associated with This Genotype

Genotype
MGI:2170323

• Allelic Composition: Aldh1a2^tm1Ipc/Aldh1a2^tm1Ipc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54067 )

• embryos die at E10.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:54067 )

• absence of organized vascular network in yolk sac

abnormal myocardium layer morphology ( J:67816 )

• some intracellular gaps; outermost layer has flattened morphology

absent myocardial trabeculae ( J:54067 )

• myocardial trabeculae are absent

thick myocardium ( J:67816 )

• thickened myocardial wall

abnormal heart development ( J:54067 , J:67816 )

• heart at E9.5 was observed as a single dilated tube of endocardial and myocardial layers (J:54067)

• abnormal posterior chamber development; hypoplastic atrial and sinus venosus regions (J:67816)

abnormal fetal atrioventricular canal morphology ( J:67816 )

• does not form

absent atrioventricular cushions ( J:67816 )

abnormal fetal cardiomyocyte morphology ( J:67816 )

• abnormal cardiomyocytes; early differentiation to sarcomeric organization

failure of heart looping ( J:54067 , J:67816 )

• mutant hearts at E9.5 did not undergo looping (J:54067)

• most embryos exhibit no signs of left-right patterning, including the heart outer curvature normally seen at E9.5 (J:67816)

• however, in many cases, a medial groove separating rostral and caudal regions is present and other anterior-posterior landmarks appear properly situated (J:67816)

enlarged heart ( J:54067 )

• dilated

embryo

abnormal vitelline vasculature morphology ( J:54067 )

• absence of organized vascular network in yolk sac

abnormal embryo turning ( J:54067 )

• most embryos do not turn

caudal body truncation ( J:54067 )

• posterior region of the embryo was shortened

decreased embryo size ( J:54067 )

• smaller than littermates after E9.5

abnormal embryonic tissue morphology ( J:54067 )

abnormal pharyngeal arch morphology ( J:54067 )

• absence of most brachial arches; only arch 1 is intact

absent hindlimb buds ( J:54067 )

• posterior limb buds were absent

absent Wolffian ducts ( J:54067 )

• absence of nephritic ducts

abnormal neural tube morphology ( J:54067 )

• irregular folding in the trunk region

incomplete caudal neuropore closure ( J:54067 )

• posterior region of the embryo remained open ventrally

abnormal somite development ( J:54067 )

• small and more densly packed somites

decreased somite size ( J:54067 )

growth/size/body

enlarged heart ( J:54067 )

• dilated

decreased embryo size ( J:54067 )

• smaller than littermates after E9.5

failure of ventral body wall closure ( J:54067 )

• lack of closure of the posterior ventral body wall

nervous system

abnormal neural tube morphology ( J:54067 )

• irregular folding in the trunk region

incomplete caudal neuropore closure ( J:54067 )

• posterior region of the embryo remained open ventrally

craniofacial

small frontonasal prominence ( J:54067 )

• frontonasal region is truncated

abnormal pharyngeal arch morphology ( J:54067 )

• absence of most brachial arches; only arch 1 is intact

muscle

abnormal myocardium layer morphology ( J:67816 )

• some intracellular gaps; outermost layer has flattened morphology

absent myocardial trabeculae ( J:54067 )

• myocardial trabeculae are absent

thick myocardium ( J:67816 )

• thickened myocardial wall

hearing/vestibular/ear

otic vesicle hypoplasia ( J:54067 )

• hypoplastic otocysts with abnormal distance from hindbrain neuroepithelium

limbs/digits/tail

absent hindlimb buds ( J:54067 )

• posterior limb buds were absent