Phenotypes Associated with This Genotype

Genotype
MGI:2171201

• Allelic Composition: Phox2b^tm1Jbr/Phox2b⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

mydriasis ( J:91199 )

• exhibit bilateral dilated pupils

behavior/neurological

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

nervous system

abnormal ciliary ganglion morphology ( J:91199 )

• exhibit severe atrophy of the ciliary ganglia at E13.5

• however, the superior cervical ganglion is normal

respiratory system

abnormal pulmonary ventilation ( J:86516 )

• exhibit an altered response to hypoxia and hypercapnia at birth; hypoxia results in a similar increase in ventilation as in wild-type but the total duration of post hypnoxic apneas is longer

decreased pulmonary ventilation ( J:86516 )

• ventilatory response to hypercapnia is markedly lower than in wild-type at P2 and P6, but not at P10