Phenotypes for Gli2 Shh MGI:2173463 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Shh^tm1Chg/Shh^tm1Chg
Genetic Background	either: (involves: 129) or (involves: 129 * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5

decreased motor neuron number ( J:73074 )

• absent from the spinal cord at E10.5

abnormal spinal cord interneuron morphology ( J:73074 )

• absent at E10.5

vision/eye

cyclopia ( J:73074 )

• at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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