Phenotypes Associated with This Genotype

Genotype
MGI:2174817

• Allelic Composition: Tg(APOC1)3Lmh/Y
• Genetic Background: C57BL/6-Tg(APOC1)3Lmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:65036 )

♂

increased circulating VLDL cholesterol level ( J:65036 )

♂ • increases in cholesterol are mainly due to elevated VLDL levels

increased circulating free fatty acids level ( J:65036 )

♂

increased circulating triglyceride level ( J:65036 )

♂

increased circulating VLDL triglyceride level ( J:65036 )

♂ • increases in triglycerides are mainly due to elevated VLDL levels

vision/eye

abnormal eye morphology ( J:65036 )

♂ • develop extensive crusts around the eyes

integument

sebaceous gland atrophy ( J:65036 )

♂

alopecia ( J:65036 )

♂ • hair loss becomes more severe upon aging, such that older mutants appear almost hairless

dry skin ( J:65036 )

♂

scaly skin ( J:65036 )

♂ • fine epidermal scaling

thick skin ( J:65036 )

♂

increased pruritus ( J:65036 )

♂ • develop pruritus

endocrine/exocrine glands

sebaceous gland atrophy ( J:65036 )

♂