Phenotypes Associated with This Genotype

Genotype
MGI:2175027

• Allelic Composition: Foxg1^tm1M/Foxg1^tm1M
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:26720 )

• all homozygotes are born alive but die within 20 minutes after birth

respiratory system

abnormal nasal placode morphology ( J:26720 )

• mutant nasal placodes fail to grow normally after E9.5

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

respiratory distress ( J:26720 )

• all newborn homozygotes make intermittent gasping motions

respiratory failure ( J:26720 )

• at autopsy, respiratory alveoli appear uninflated, indicating respiratory failure

nervous system

abnormal telencephalon morphology ( J:26720 )

• at E12.5, the dorsal telencephalon is reduced in size whereas the ventral telencephalon is nearly absent

abnormal telencephalon development ( J:26720 )

• development of the ventral telencephalon is more severely affected than that of the dorsal telencephalon

• proliferation of ventral telencephalic neuroepithelium is reduced progressivley such that growth stops at E10.5

• abnormal proliferation of dorsal telencephalic neuroepithelium becomes more severe as development proceeds

• at E12.5, dorsal telencephalic vesicles are positioned more ventrally and closer to the level of the eyes

small embryonic telencephalon ( J:26720 )

• by E10.5, mutant brains exhibit significantly smaller telencephalic vesicles; this size difference is pronounced at E12.5

abnormal cerebral hemisphere morphology ( J:26720 )

• newborn homozygotes exhibit a 95% mass reduction of the cerebral hemispheres which rest on the dorsolateral surface of the diencephalon

abnormal cerebral cortex morphology ( J:26720 )

• at E12.5, mutant brains display an uneven cerebral cortex due to buckling of the neuroepithelium and to variations in cortical tissue thickness

small olfactory bulb ( J:26720 )

• mutant olfactory bulbs are significantly smaller than wild-type

abnormal embryonic/fetal subventricular zone morphology ( J:26720 )

• at E12.5, mutant ganglionic eminences are replaced by a thin neuroepithelium

craniofacial

abnormal cranium morphology ( J:26720 )

• newborn homozygotes display flattening of the frontal skull

abnormal nasal placode morphology ( J:26720 )

• mutant nasal placodes fail to grow normally after E9.5

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

vision/eye

abnormal eye morphology ( J:26720 )

• newborn homozygotes display ellipsoid instead of round eyes

• ventral rotation of the entire eye is observed at E12.5

abnormal retina morphology ( J:26720 )

• newborn homozygotes display an irregular retinal contour, that is pronounced in the nasal retina

abnormal retina neuronal layer morphology ( J:26720 )

• at E12.5, mutant eyes display a wavy anterior retinal neuroepithelium

homeostasis/metabolism

cyanosis ( J:26720 )

• all newborn homozygotes appear cyanotic

behavior/neurological

no spontaneous movement ( J:26720 )

• newborn homozygotes are flaccid and exhibit minimal spontaneous movement

skeleton

abnormal cranium morphology ( J:26720 )

• newborn homozygotes display flattening of the frontal skull

taste/olfaction

abnormal nasal placode morphology ( J:26720 )

• mutant nasal placodes fail to grow normally after E9.5

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

growth/size/body

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5