Phenotypes Associated with This Genotype

Genotype
MGI:2175128

• Allelic Composition: Myf6^tm1Eno/Myf6^tm1Eno
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal rib morphology ( J:26105 )

• rib anomalies are bilaterally asymmetric and appear to occur randomly in different ribs but show 100% penetrance

• newborns show supernumerary processes in the distal regions of the ribs

abnormal rib development ( J:26105 )

• many ribs appear to emerge from the vertebral bodies at incorrect angles

rib bifurcation ( J:26105 , J:42453 )

• multiple bifurcations (J:26105)

short ribs ( J:42453 )

• distal parts of ribs are missing resulting in short ribs

muscle

muscle phenotype ( J:26105 )

N • homozygotes exhibit normal distribution of fast- and slow-twitch muscle fibers and normal somite myogenesis

abnormal extraocular muscle morphology ( J:150130 )

• mice have mild extraocular muscle defects compared to Myf5^tm2Tajb homozygotes

abnormal myotome development ( J:42453 )

• myotomes consist of very few myocytes at E10.5 and the myocytes are poorly organized relative to each other, resulting in misshapen and small myotomes

vision/eye

abnormal extraocular muscle morphology ( J:150130 )

• mice have mild extraocular muscle defects compared to Myf5^tm2Tajb homozygotes