Phenotypes Associated with This Genotype

Genotype
MGI:2175129

• Allelic Composition: Myf6^tm1Thbr/Myf6^tm1Thbr
• Genetic Background: either: (involves: 129S4/SvJae-Myf6^tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:24360 )

• die within a few minutes after birth

embryo

abnormal somite development ( J:24360 )

• embryos show a lack of primary myocytes in somites between E9.5 and E10.5

skeleton

abnormal sternocostal joint morphology ( J:24360 )

• lack the distal parts of the ribs and thus no contacts with the sternum are made

abnormal rib morphology ( J:24360 )

short ribs ( J:24360 , J:31636 )

• lack the distal parts of the ribs (J:24360)

• ribs are shorter than in wild-type but are somewhat longer than in Myf5^tm1Jae mice (J:31636)

abnormal sternum ossification ( J:24360 )

• sternum is completely ossified

muscle

abnormal muscle morphology ( J:24360 )

• significant decrease in muscle fibers of the deep axial muscles at several locations along the rostro-caudal axis (the deep back muscles)