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Phenotypes Associated with This Genotype
Genotype
MGI:2175210
Allelic
Composition
Agtpbp1pcd/Agtpbp1pcd
Genetic
Background
involves: C57BR/cdJ * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtpbp1pcd mutation (2 available); any Agtpbp1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• age of onset, 3 - 4 weeks

nervous system
• thalamic neuronal degeneration, age of onset 50 - 60 days
• olfactory mitral cell degeneration, slow and progressive
• climbing fibers never contact Purkinje cells (J:23733)
• symmetrical regions of more resistant cells but most disappear eventually (J:106414)
• age of onset, 15 - 18 days
• atrophic dendritic trees
• cell loss begins at 3 weeks of age and progresses rapidly
• about 1% of initial population remains at 2 months of age
• granule cell degeneration, partial loss following Purkinje cell degeneration
• photoreceptor cell degeneration, age of onset, 18 - 25 days
• complete over the course of 1 year

vision/eye
• photoreceptor cell degeneration, age of onset, 18 - 25 days
• complete over the course of 1 year

reproductive system
• of the few sperm found, these were degenerated
• females were poor breeders

cellular
• of the few sperm found, these were degenerated


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory