Analysis Tools
homeostasis/metabolism
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• at 6-10 weeks, male hemizygotes exhibit a slight but significant reduction in blood glucose levels in both the fasted and fed states; however, these differences become statistically insignificant at 6 months
• in contrast, plasma insulin levels remain unaffected in the fed and fasted state at both ages
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• at 6-10 weeks, male hemizygotes show a slightly impaired glucose tolerance, with significant differences noted at the 90 and 120 min time points
• at 6 months, significant differences are only noted at the 20 min point of the oral glucose tolerance test
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reproductive system
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• male hemizygotes exhibit reduced ability to produce live offspring when mated with homozygous mutant females
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• pairs of mutant mice produce an average of 1.8 0.4 litters per pair (range 0-3 litters) over a 3-month period, whereas wild-type mice produce an average of 2.9 0.1 litters per pair (range 2-3 litters)
• 36% of mutant litters die within a few days of birth relative to only 5% of wild-type litters
• the average size of surviving litters from mutant mice is slightly reduced relative to wild-type litters
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growth/size/body
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• at 9 weeks and beyond, the weight of male hemizygotes is ~10% less that of wild-type mice
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• male hemizygotes exhibit a growth retardation beyond 6 weeks of age
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