Phenotypes Associated with This Genotype

Genotype
MGI:2176439

• Allelic Composition: Sos1^tm1Dlb/Sos1^tm1Dlb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:38321 )

• die after E12, but before birth

cardiovascular system

abnormal cardiovascular system morphology ( J:38321 )

• Background Sensitivity: homozygotes on a 129 background exhibit similar phenotypes as those on a mixed 129 and C57BL/6J background, however they are more severely and more often affected

abnormal blood vessel morphology ( J:38321 )

• major vessels are distended

blood vessel congestion ( J:38321 )

• major vessels are congested

abnormal myocardial trabeculae morphology ( J:38321 )

• myocardium shows reduced trabeculation

abnormal heart atrium morphology ( J:38321 )

• the atria are often congested with blood

abnormal heart position or orientation ( J:38321 )

• orientation of the heart is abnormal

enlarged heart ( J:38321 )

abnormal heart ventricle morphology ( J:38321 )

• ventricles are often congested with blood

distended pericardium ( J:38321 )

• distended pericardium

hemorrhage ( J:38321 )

craniofacial

cleft palate ( J:38321 )

• seen occasionally

embryo

decreased embryo size ( J:38321 )

• from E9 onward, embryos are smaller than controls

pale yolk sac ( J:38321 )

• yolk sacs are severely depleted of nucleated red cells

nervous system

abnormal midbrain morphology ( J:38321 )

• occasionally see gross malformations of the mid-brain region

growth/size/body

enlarged heart ( J:38321 )

cleft palate ( J:38321 )

• seen occasionally

decreased embryo size ( J:38321 )

• from E9 onward, embryos are smaller than controls

muscle

abnormal myocardial trabeculae morphology ( J:38321 )

• myocardium shows reduced trabeculation

digestive/alimentary system

cleft palate ( J:38321 )

• seen occasionally